Nod1 Plays a Causal Role in Palmitate-Induced β-Cell Dysfunction In Vitro and In Vivo in Male Mice.

Authors

Justin H M Yung, Emily G Hoffman, Aleksandar Ivovic, S M Niazur Rahman, Tejas Desai, Khajag Koulajian, Yusaku Mori, Charles Maisonneuve, Marry Nissan, Ayse Bengisu Gelmez, Yasmin Rabiee, Sandra Pereira, Dana Al-Rijjal, Michael B Wheeler, Dana J Philpott, Adria Giacca, Kacey J Prentice

Published in

Diabetes. Sep 22, 2026. Epub Sep 22, 2026.

Abstract

The innate immunity receptor nucleotide-binding oligomerization domain 1 (Nod1) can be activated by saturated fatty acids and is implicated in high-fat diet-induced inflammation and insulin resistance. This implies Nod1 plays a role in glucose homeostasis; therefore, we sought to determine whether saturated fatty acids cause pancreatic β-cell dysfunction through Nod1. Our data demonstrate that Nod1 is involved in palmitate-induced β-cell dysfunction in vitro and in vivo.

PMID:
42770987
Bibliographic data and abstract were imported from PubMed on 22 Sep 2026.

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