A NIR-II emissive theranostic nanomedicine with mitochondrial-biomimetic coating for imaging-guided phototherapy of pancreatic tumors.

Authors

Jie Chen, Jie Zhang, Xin Xu, Wenchang Xu, Ping Cui, Ting Liu, Qi Zhao, Ning Li, Shengliang Li

Published in

Journal of materials chemistry. B. Sep 22, 2026. Epub Sep 22, 2026.

Abstract

The deep-seated nature of pancreatic cancer and paucity of effective interventions render it a particularly devastating malignancy, highlighting the need for precise imaging-guided theranostic strategies. Here, we have developed a mitochondrial-biomimetic, second near-infrared (NIR-II) emissive theranostic nanomedicine (mNPs) based on a rationally engineered boron-dipyrromethene derivative for imaging-guided synergistic phototherapy. The mNPs were coated with homologous mitochondrial membranes to enhance cellular internalization and mitochondrial targeting. Upon NIR laser irradiation, the mNPs displayed intense NIR-II emission, effective reactive oxygen species (ROS) production, and remarkable photothermal activity, achieving a photothermal conversion efficiency of 77.1%. The strong NIR-II emission enabled real-time tumor visualization and guided therapeutic intervention. In vivo studies demonstrated complete tumor eradication without recurrence, accompanied by immunogenic cell death and favorable biosafety. This work presents a mitochondrial-biomimetic NIR-II nanoplatform for precise imaging-guided phototherapy of pancreatic tumors.

PMID:
42770723
Bibliographic data and abstract were imported from PubMed on 22 Sep 2026.

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