Molecular Design and Anticancer Activities of Small-Molecule BRAF Inhibitors: A Medicinal Chemistry Perspective.

Authors

Shuyu Jia, Jieman Lin, Janjun Wu, Hao Xu, Qingwei Zeng, Meipin Liu, Jiayi Shen

Published in

Drug development research. Volume 87. Issue 7. Pages e70389.

Abstract

BRAF is a cytoplasmic serine-threonine protein kinase that plays a critical role in the MAPK signaling pathway. BRAF is the only member of the RAF family activated by mutation in human cancers. Many classes of B-Raf small molecule inhibitors have been identified. In this review, we will highlight typical BRAF inhibitors developed during these decades and provide a reference for the exploration of more potential BRAF inhibitors in the future.

PMID:
42770398
Bibliographic data and abstract were imported from PubMed on 22 Sep 2026.

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