Authors
Priya D Samalia, Krish Sethi, Lyndell Lim, Shaikha Aljneibi, Stephen Guest, Elisa E Cornish, Peter McCluskey, Helen Zhang, Joanne Sims, Rachael L Niederer
Published in
Ocular immunology and inflammation. Pages 1-10. Sep 23, 2026. Epub Sep 23, 2026.
Abstract
To characterise the spectrum of clinical presentations of Bartonella-associated uveitis across multiple tertiary uveitis centres and assess the frequency of non-neuroretinitis phenotypes.
Multi-centre retrospective case series of patients with serologically confirmed Bartonella infection and associated intraocular inflammation. Clinical phenotypes were classified as classical (isolated neuroretinitis) or non-neuroretinitis based on anatomic and multimodal imaging findings, and their relative frequencies were analysed.
Seventy eyes of 53 patients were included. Median presenting best-corrected visual acuity was 20/50 (IQR 20/20 to 20/400). Posterior uveitis (57.1%) and panuveitis (30.0%) were the most frequent anatomical classifications. Neuroretinitis was present in 35 (50.0%) eyes. Non-classical manifestations were common and included optic neuritis (34.3%), multifocal retinitis (30.0%), isolated papillitis (24.3%), retinal vascular occlusion (18.6%), and multifocal choroiditis (11.4%).
Non-neuroretinitis manifestations of Bartonella-associated uveitis comprise a substantial proportion of presentations in tertiary uveitis practice. Although these phenotypes have been individually described previously, our findings emphasise that Bartonella infection should remain an important differential diagnosis across a broad spectrum of posterior segment inflammatory presentations rather than being considered predominantly a cause of neuroretinitis.
PMID:
42773980
Bibliographic data and abstract were imported from PubMed on 23 Sep 2026.
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