Subtlety is underrated: Physiological UPR activation in meiosis.

Authors

David Pincus, Vladimir Denic

Published in

The Journal of cell biology. Volume 225. Issue 10. Oct 05, 2026. Epub Sep 23, 2026.

Abstract

In this issue, Bartolutti et al. (https://doi.org/10.1083/jcb.202509100) identify a physiological function for the unfolded protein response (UPR). The UPR has long been viewed as a coping mechanism for protein misfolding in the endoplasmic reticulum (ER). The authors here show that budding yeast naturally use this response to reorganize their ER during meiosis and sporulation, suggesting an ancient origin for the UPR as an adaptive developmental program.

PMID:
42776151
Bibliographic data and abstract were imported from PubMed on 23 Sep 2026.

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