A self-powered biosensing platform for U937 cell detection and the induction of mitochondrial aggregation.

Authors

Wenwen Xu, Yalong Qiao, Qiuting Wang, Lei Feng, Pinghua Ling

Published in

Chemical communications (Cambridge, England). Sep 23, 2026. Epub Sep 23, 2026.

Abstract

An EBFC platform was developed for U937 cell detection via aptamer-triggered glucose oxidation. The generated electrons reduced cathode Fe³⁺, disrupting an alginate hydrogel to release mitochondrial-targeting nanoparticles. Intracellularly, ATP-induced DNA hybridization caused mitochondrial aggregation and ROS-mediated intervention, achieving closed-loop cancer diagnostics and intervention.

PMID:
42775686
Bibliographic data and abstract were imported from PubMed on 23 Sep 2026.

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