Visible-light-driven carbamoyl radical addition to 3-methylene isoindolinones.

Authors

Nathan Martin, Roberto Doville, Lou-Anne Beghin, Anaïs Lachemet, Thomas Beaugrand, Eric Deniau, Lydie Pélinski, Till Bousquet

Published in

Organic & biomolecular chemistry. Sep 23, 2026. Epub Sep 23, 2026.

Abstract

An efficient method for the synthesis of 3-substituted isoindolinones is described. The addition of a carbamoyl group from carbamoyl-dihydropyridine onto 3-methylene isoindolinones provides amide functionalization under visible light irradiation, in the presence of an organic photocatalyst. This protocol offers mild reaction conditions, a broad substrate scope, and an excellent functional group tolerance, affording a range of structurally diverse 3-amido isoindolinones in good to excellent yields.

PMID:
42776147
Bibliographic data and abstract were imported from PubMed on 23 Sep 2026.

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