Authors
Norbertus A Ipenburg, Anton C de Groot, Thomas Rustemeyer
Published in
Contact dermatitis. Sep 23, 2026. Epub Sep 23, 2026.
Abstract
Reproducibility of patch test reactions remains debated, and the clinical significance of doubtful (?+) reactions is unclear.
To evaluate reproducibility of positive reactions to identical haptens tested simultaneously in different series and analyse doubtful reactions using paired co-reactivity patterns.
Patch test data from consecutive patients tested during 2015-2025 were analysed retrospectively. Six haptens were evaluated at standard concentrations in petrolatum: hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral, HICC) 5% pet., Amerchol L-101 50% pet., lanolin alcohol 30% pet., hydroxyethyl methacrylate (HEMA) 2% pet., mercaptobenzothiazole (MBT) 2% pet. and Myroxylon pereirae resin (balsam of Peru, MPR) 25% pet.
Reproducibility was hapten-dependent. HEMA and MBT showed substantial to almost perfect agreement. HICC showed substantial agreement but a significantly higher positivity rate in the perfume series than in the baseline series. Amerchol L-101, lanolin alcohol and MPR showed lower positive agreement and fair-to-moderate kappa values. Most doubtful reactions were isolated, particularly for Amerchol L-101 and lanolin alcohol, whereas 43.8% of doubtful HICC reactions in the baseline series were supported by perfume-series reactivity.
Reproducibility was strongly hapten-dependent. In this dataset, paired co-reactivity provided clinical context for interpreting discordant positive and doubtful reactions.
PMID:
42775713
Bibliographic data and abstract were imported from PubMed on 23 Sep 2026.
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