Myeloid infiltration and epidermal dysregulation characterize cutaneous photosensitivity in systemic lupus erythematosus.

Authors

Mitra P Maz, Lin Zhang, Feiyang Ma, Mehrnaz Gharaee-Kermani, Benjamin Klein, Rezvan Moallemian, Nguyen Nguyen, Yuli Cai, Shannon N Loftus, Allison C Billi, Lisa Abernathy-Close, Moriah Ma, Rachael Bogle, Amy Hurst, Lam C Tsoi, Johann E Gudjonsson, J Michelle Kahlenberg

Published in

Science translational medicine. Volume 18. Issue 868. Pages eadw1914. Sep 23, 2026. Epub Sep 23, 2026.

Abstract

For patients with systemic lupus erythematosus (SLE), sun avoidance and sunscreen use are the only preventive therapies for photosensitivity, a process by which exposure to ultraviolet (UV) light triggers cutaneous and systemic flares of disease. Photosensitivity is exceedingly common among patients with SLE who develop rashes, affecting up to 93% of this population. Treatment of skin and systemic disease triggered by the sun can be challenging, and thus there exists a critical need for better therapeutic and preventative strategies. Innovation of targeted therapies for photosensitive skin diseases requires a precise dissection of the cellular players and signaling pathways that contribute to aberrant inflammation after UV exposure. Here, we used cutaneous UVB photoexposure of healthy controls and patients with SLE to provide an atlas of the cutaneous inflammatory response 24 hours after UV exposure in single-cell resolution. We demonstrate that the epidermis is dysregulated in lupus, where epidermal-dermal cross-talk in SLE is dominated by inflammatory keratinocytes after UV exposure in contrast with the healthy control epidermis. In both healthy controls and patients with SLE, the downstream consequence of UV exposure is the recruitment of a population of monocyte-derived dendritic cells (moDCs). Although moDCs are present in relatively equal proportions in SLE and healthy control UV-treated skin, they appear to be derived from distinct circulating monocyte populations. SLE UV moDCs are characterized by inflammatory and antigen presentation pathways and may represent a precursor to lesional cutaneous lupus CD16⁺ DCs, identifying a potential link between cutaneous UV responses and cutaneous lupus flare.

PMID:
42777086
Bibliographic data and abstract were imported from PubMed on 24 Sep 2026.

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