Cronkhite-Canada Syndrome Associated with Primary Cutaneous Peripheral T-cell Lymphoma and Membranous Nephropathy: A Case Report.

Authors

Kohei Kiso, Yusuke Shimoyama, Saki Okuda-Hiwatashi, Taku Fujimura, Yoshihide Asano, Rui Makino, Tetsuhiro Tanaka, Hideya Iwaki, Daisuke Okamoto, Hiroshi Nagai, Takeo Naito, Rintaro Moroi, Yoichi Kakuta, Atsushi Masamune

Published in

Internal medicine (Tokyo, Japan). Sep 22, 2026. Epub Sep 22, 2026.

Abstract

Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by gastrointestinal polyposis and ectodermal abnormalities. We report the case of a 64-year-old man with CCS complicated by primary cutaneous peripheral T-cell lymphoma (PC-PTCL) and membranous nephropathy. Cutaneous lymphoma was controlled using topical corticosteroids and phototherapy. During the clinical course of CCS, the patient developed proteinuria, and a renal biopsy revealed membranous nephropathy with equivocal phospholipase A2 receptor staining. Corticosteroid therapy improved both the gastrointestinal manifestations and proteinuria. This case suggests a possible immune-mediated association among CCS, PC-PTCL, and membranous nephropathy.

PMID:
42778376
Bibliographic data and abstract were imported from PubMed on 24 Sep 2026.

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