A Cluster of Influenza A(H3N2) Viruses in 2024 From Tasmania, Australia, With Reduced Susceptibility to Baloxavir.

Authors

Saira Hussain, Charmaine Chia, Ashwin Muraleetharan, Yi-Mo Deng, Xiaomin Dong, Presa Chanthalavanh, Emi Takashita, Clyde Dapat, Jessica E Miller, Heidi Peck, Raphael T C Lee, Jan Williamson, Louise Cooley, Sebastian Maurer-Stroh, Ian G Barr

Published in

Influenza and other respiratory viruses. Volume 20. Issue 9. Pages e70312.

Abstract

The emergence of viruses with reduced susceptibility to antivirals poses an ongoing risk which could limit their effectiveness. Here we report a cluster of A(H3N2) viruses detected in Tasmania, Australia, with a PA gene mutation A37T that showed mild reductions in susceptibility in vitro to baloxavir (3.47- to 16.33-fold increased EC₅₀) when compared to wild-type influenza A(H3N2) viruses. When the PA-A37T and PA-I38T substitutions were combined and tested in IRINA assay, eightfold higher inhibition was seen compared to PA-I38T alone. On-going monitoring of influenza viruses for reduced susceptibility to antivirals remains an important part of seasonal and zoonotic influenza surveillance.

PMID:
42778508
Bibliographic data and abstract were imported from PubMed on 24 Sep 2026.

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