Papulosquamous secondary syphilis with palmoplantar sparing: A case illustrated.

Authors

Varun H, Adarshlata Singh, Bhushan Madke, Naman Kacchawa, Aryan Pal

Published in

IDCases. Volume 46. Pages e02773. Epub Sep 15, 2026.

Abstract

Secondary syphilis is a clinical mimic with considerable morphological variability. We describe a man in his early 50s with a generalised papulosquamous eruption, constitutional symptoms and generalised lymphadenopathy, notably without palmoplantar involvement. Syphilis serology was strongly reactive, and histopathology demonstrated a plasma cell-rich superficial and deep perivascular and peri-adnexal infiltrate. This case illustrates the importance of considering secondary syphilis in generalised papulosquamous eruptions despite the absence of classical palmoplantar lesions.

PMID:
42779958
Bibliographic data and abstract were imported from PubMed on 24 Sep 2026.

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