Matters of the Heart and Soul: The Mixed Impact of Religiosity and Spirituality on the Cardiovascular Risk Profile Over Time.

Authors

Vinicius Vieira Neves, Cesar de Oliveira, LaPrincess C Brewer, Ione Jayce Ceola Schneider, Andrew Steptoe

Published in

medRxiv : the preprint server for health sciences. Sep 20, 2026. Epub Sep 20, 2026.

Abstract

Religiosity and spirituality (R/S) are generally associated with a more favourable cardiovascular risk profile, but longitudinal evidence is limited. We examined whether multidimensional R/S predicts its future behavioural and biological components.
This prospective cohort study analysed 6,844 adults aged ≥50 (56% women; mean R/S score 2.1; 20% weekly attenders; 81% Christian) from waves 4-7 of the English Longitudinal Study of Ageing (ELSA). Behavioural outcomes included smoking, exercise, alcohol intake, and fruit and vegetable consumption; biological outcomes included blood pressure (BP), haemoglobin A1c (HbA1c), and the inflammatory risk markers C-reactive protein (CRP) and fibrinogen. R/S was assessed with four items from the Santa Clara Strength of Religious Faith Questionnaire. Hierarchical linear and logistic regressions adjusted for age, sex, wealth, education and ethnicity; biomarker models also adjusted for health behaviours and body mass index.
Greater spirituality (B=-0.019; 95%CI[-0.036,-0.003]), daily prayer/meditation (B=-0.017; 95%CI[-0.032,-0.002]), participation in organized religion (B=-0.017; 95%CI[-0.032,-0.002]), and importance of religious faith (B=-0.017; 95%CI[-0.033,-0.002]) were independently associated with lower fibrinogen levels. Daily prayer/meditation also independently predicted higher fruit and vegetable intake (B=0.004; 95%CI[0.000,0.008]). However, frequent attendance (OR=0.846; 95%CI[0.730,0.982]), the significance of faith (OR=0.935; 95%CI[0.879,0.994]), and religious purpose (OR=0.939; 95%CI[0.884,0.997]) independently reduced the odds of meeting exercise recommendations. Similarly, frequent attendance was associated with higher HbA1c (B=0.002; 95%CI[0.000,0.005]). There were no independent associations with CRP or blood pressure.
R/S showed mixed prospective associations with the cardiovascular risk profile: favourable for fibrinogen and fruit and vegetable intake, unfavourable for physical activity and HbA1c.

PMID:
42780291
Bibliographic data and abstract were imported from PubMed on 24 Sep 2026.

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