Authors
Jennifer Schomaker, Elijah Marris, Amir Johnson-Sammy, Brandon Davis, Davis Fowler, Emanuele Casali, Dilhumar Uyghur, Nicholas Onuska, Jon Day, Xiaoyong Li, Giuseppe Zanoni
Published in
Research square. Sep 17, 2026. Epub Sep 17, 2026.
Abstract
Radical identity is traditionally coupled to the strategy required for its generation, necessitating distinct precursor classes and activation modes to furnish different reactive intermediates. Here, we introduce a modular redox-release platform that provides programmable access to diverse S(VI) and fluoroalkyl radicals from a common proline-derived scaffold, decoupling the radical identity from precursor activation. Complementary oxidative and reductive activation pathways converge on a shared α-amino radical intermediate to furnish chemically distinct radicals. The platform exhibits broad utility in hydrofunctionalization, late-stage functionalization, synthetic diversification, and target-oriented synthesis, while mechanistic and computational studies suggest a common β-scission pathway underlying its generality. More broadly, redox-release establishes a strategy in which activation mode and radical identity become independent design parameters for radical generation.
PMID:
42780245
Bibliographic data and abstract were imported from PubMed on 24 Sep 2026.
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