Authors
Mouna Riguen, Hanen Chaker, Najla Dammak, Mohamed Ben Hmida, Tahya Boudawara, Ikram Agrebi, Khawla Kammoun
Published in
Nephrologie & therapeutique. Volume 22. Issue 4. Pages 1-9. Aug 01, 2026.
Abstract
The response to corticosteroid therapy in idiopathic nephrotic syndrome (INS) is variable. Glucocorticoid receptors (GR), which are essential for steroid action, may partly explain this variability.To investigate the relationship between podocyte glucocorticoid receptor expression assessed by immunohistochemistry and the response to corticosteroid therapy in INS.
This was a retrospective study conducted over a 22-year period, including 29 patients with minimal change disease or primary focal segmental glomerulosclerosis. Podocyte GR expression was evaluated by immunohistochemistry and correlated with treatment response.
In total, 18 patients were steroid-sensitive, 6 were steroid-dependent, and 5 were steroid-resistant. No conventional clinical, laboratory, or histological factor was predictive. However, GR expression was higher in steroid-sensitive than in steroid-resistant patients (p = 0.046).
Podocyte glucocorticoid receptor expression may predict the response to corticosteroid therapy in idiopathic nephrotic syndrome.
PMID:
42781851
Bibliographic data and abstract were imported from PubMed on 25 Sep 2026.
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