Comparison of Health Status Among Patients With Type 1 Myocardial Infarction and Type 2 Myocardial Infarction: The CHAMP-MI Study.

Authors

Seán P Murphy, Nhi Tong, Jeff C Huffman, Elaine Luterstein, Avanthi Raghavan, Charlotte Paquette, Claire Lin, Yuxi Liu, Jason H Wasfy, Gheorghe Doros, Dalane W Kitzman, Pradeep Natarajan, James L Januzzi, John A Spertus, Cian P McCarthy

Published in

Journal of the American Heart Association. Pages e050146. Sep 24, 2026. Epub Sep 24, 2026.

Abstract

Improving health status is a fundamental goal after myocardial infarction (MI). Whether health status differs between type 1 and type 2 MI is unknown.
In this prospective study, 150 patients hospitalized with type 1 (n=75) and type 2 MI (n=75) were enrolled. Health status was assessed at baseline, 1, and 4 months using the EuroQol 5-Dimension 5-Level visual analogue scale, 7-item Seattle Angina Questionnaire, Patient-Reported Outcomes Measurement Information System Physical Function, Patient-Reported Outcomes Measurement Information System Fatigue, FRAIL Scale, and Patient Health Questionnaire-9.
A total of 149 baseline, 92 one-month, and 92 four-month assessments were analyzed. Patients with type 2 MI were older, were more frequently women, and had more comorbidities. Baseline health status was similar between type 2 and type 1 MI (EuroQol 5-Dimension 5-Level visual analog scale, 66.20±22.17 versus 69.36±20.67; P=0.37). At 1 and 4 months, the EuroQol 5-Dimension 5-Level visual analog scale was lower for type 2 MI, and adjusted analyses demonstrated less improvement (difference, - 4.8 points; P=0.04). Patients with type 2 MI had lower physical function and greater frailty throughout follow-up. Baseline fatigue and depression were similar but modestly worse for type 2 MI at follow-up. Baseline 7-item Seattle Angina Questionnaire scores were higher for type 2 MI but were similar between groups at follow-up.
Although baseline overall health status was similar, patients with type 2 MI experienced smaller improvements in health status and reported a greater burden of frailty and impaired physical function over 4 months. These findings highlight the need to address health status domains beyond angina after type 2 MI.

PMID:
42786649
Bibliographic data and abstract were imported from PubMed on 25 Sep 2026.

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