Authors
Mohamed J Saadh, Tamara Nazar Saeed, Karar H Alfarttoosi, Gaurav Sanghvi, R Roopashree, Vishal Thakur, L Lakshmi, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Ali M Ali Al-Nuaimi, Bagher Farhood
Published in
International journal of preventive medicine. Volume 17. Pages 86. Epub Aug 31, 2026.
Abstract
This study assesses the impact of vitamin D supplementation on serum cholecalciferol levels and some cytokines in colorectal cancer (CRC) patients.
We conducted a thorough search for relevant RCTs in PubMed, Scopus, and Google Scholar using appropriate keywords until December 2024. We calculated weighted mean differences (WMDs) and 95% confidence intervals (CIs) through random-effects analysis.
Five studies were included. Combining data from four studies showed a significant increase in serum 25 (OH) cholecalciferol levels after supplementation (WMD: 23.72; 95% CI: 12.92, 34.52). However, results from two studies indicated no significant changes in serum CRP (WMD: -2.48; 95% CI: -7.42, 2.46) and IL-6 (WMD: -2.49; 95% CI: -6.89, 1.92) levels. Conversely, TNF-α significantly decreased after administration (WMD: -0.81; 95% CI: -1.18, -0.45). There were no significant changes in anti-inflammatory cytokine IL-10 levels (WMD: 0.29; 95% CI: -0.43, 1.01).
This study demonstrates a significant rise in serum 25 (OH) cholecalciferol and a significant decrease in TNF-α, with no notable changes in serum CRP, IL-6, and IL-10 levels in CRC patients after vitamin D treatment.
PMID:
42788453
Bibliographic data and abstract were imported from PubMed on 25 Sep 2026.
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