Type 2 Angiotensin II receptor (AT2R) deficiency exacerbates cardiac senescence and fibrosis in aging mice.

Authors

Larissa Maria Zacarias-Rodrigues, Aline Cristina Parletta, Marina Reingruber Fevereiro, Tábatha de Oliveira Silva, Wenddy Wyllie Damasceno Sougey, Nathalia Senger, Michael Bader, Ana Paula Cremasco Takano, Robson Augusto Souza Dos Santos, Maria Luiza Morais Barreto-Chaves

Published in

Clinical science (London, England : 1979). Sep 25, 2026. Epub Sep 25, 2026.

Abstract

Cardiac aging increases susceptibility to cardiovascular diseases. Cellular senescence may be involved in the development of age-related cardiac diseases. Extensive evidence derived from both clinical and experimental studies suggest that the Type 2 Angiotensin II receptor (AT2R) exerts a potent cardioprotective effect, however, its potential contribution to age-related cardiac complications remains unknown. In this study we used AT2R knockout (AT2-KO) and wild-type mice (WT) both aged (18-21-month-old) and young (4-5-month-old) and evaluated the repercussions cardiac of aging. Old AT2-KO mice exhibited impaired systolic and diastolic cardiac function and exacerbated fibrosis accompanied by increased fibrotic markers expression. The absence of AT2R accelerated the cardiac senescence process in old mice, evidenced by early increase in p53 and p21. In addition, aged AT2-KO mice showed increased expression of Senescence-Associated Secretory Phenotype (SASP) components, activation of cardiac NF-kB and NLRP3-inflammasome followed by increased levels of cardiac IL-1β and IL-18 compared to aged WT mice. AT2R deficiency also resulted in significant DNA damage even in young animals and it was associated with a 5-month reduction in median lifespan (26 months for AT2R-KO vs. 31 months for WT). These findings suggest potential mechanisms whereby AT2R acts as a key mediator of cardiac senescence and cardioprotection during aging.

PMID:
42788951
Bibliographic data and abstract were imported from PubMed on 25 Sep 2026.

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