Navigating clozapine discontinuation in clinical practice: An updated framework.

Authors

Grace Charter, Nadezda Asceric, Prashant Tibrewal, Tarun Bastiampillai

Published in

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists. Pages 10398562261491662. Sep 25, 2026. Epub Sep 25, 2026.

Abstract

Clozapine remains the most effective treatment for treatment-resistant schizophrenia (TRS), yet clinicians are frequently faced with situations where discontinuation must be considered due to adverse effects, patient preference, or lack of effectiveness. This article proposes an eight-step, clinically informed approach to guide the safe planning, implementation, and monitoring of clozapine discontinuation.

PMID:
42788864
Bibliographic data and abstract were imported from PubMed on 25 Sep 2026.

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