Role of Respiratory Viral Infections in Airflow Obstruction After Hematopoietic Cell Transplantation.

Authors

Sapna A Pardasani, Ali Y Suliman, Jose A Ferrolino, Ronald H Dallas, Megan Peterson, Pamela Merritt, Amanda Cole, Amber Davis, Ashleigh Gowen, Kim J Allison, Randall T Hayden, Ying Li, Dinesh Keerthi, Saumini Srinivasan, Gabriela M Maron, Brandon M Trilplett, Diego R Hijano

Published in

Pediatric transplantation. Volume 30. Issue 9. Pages e70467.

Abstract

Respiratory viral infections (RVIs) in allogeneic hematopoietic cell transplant (allo-HCT) recipients can cause airflow obstruction (AFO). Despite this risk, the impact of community-acquired RVI on PFTs in pediatric patients after allo-HCT remains unclear.
The study determines the role of RVI in the development of AFO post-transplant among survivors of allo-HCT.
This retrospective study analyzed St. Jude patients undergoing allo-HCT between 2003-2020. AFO was defined by z-scores and forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio expressed as lower limit of normal (LLN). Baseline parameters were obtained before allo-HCT, and Year 1 parameters within 425 days post allo-HCT. Spirometry measures were calculated using the global lung function Initiative (GLI) calculator. Bivariate and multivariate logistic regression identified risk factors for AFO following allo-HCT.
A total of 397 patients were included, with a median age of 12.7 years. RVI occurred in 13% of patients within the first 100 days after transplantation. AFO developed in 12% of patients. Among those with AFO, 68% had a baseline FEV1/FVC ratio above the LLN, and 11% had a history of lower respiratory tract infection (LRTI) (p < 0.05). The median time from transplant to RVI was shorter in patients with AFO (12 vs. 34 days). A baseline LLN value was a significant predictor of AFO. However, after adjusting for known covariates, RVI was not independently associated with AFO risk.
RVIs within 100 days of allo-HCT did not significantly affect AFO following transplant in pediatric patients.

PMID:
42790878
Bibliographic data and abstract were imported from PubMed on 26 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.