Centering Black Voices: Factors Influencing a Cancer Patient's Decision to Join a Clinical Trial.

Authors

Charlyn Gomez, Caitlin Eggleston, Matthew Ferris, Jason Molitoris, Zaker Rana, Sarah McAvoy, Elizabeth Nichols, William Regine, Wendla Citron, Søren M Bentzen, Melissa Ana Liriano Vyfhuis

Published in

International journal of radiation oncology, biology, physics. Sep 25, 2026. Epub Sep 25, 2026.

Abstract

The enrollment of Black patients (BP) in cancer-related clinical trials has recently declined and its etiology remains poorly understood. We aim to characterize psychosocial factors that influence patients with curative gastrointestinal, thoracic, gynecological, and head and neck malignancies when enrolling in a research trial, to improve recruitment and retention of BP.
We conducted a cross-sectional, descriptive study using a questionnaire adapted from two validated surveys to patients who completed definitive radiation treatment for the aforementioned malignancies. Chi-square and Mann-Whitney U tests assessed differences between the populations.
From October 2023 to February 2024, 172 out of 247 eligible patients agreed to participate (survey participation 70%). BP comprised 24% of patients who participated (n=42). BP were less likely to be married (16.7%vs.68.8%;p<.001), have a Bachelor's (9.5%vs.24.2%;p=.048), or Graduate degree (2.4%vs14.1%;p=.046), and a lower median income ($69,318vs.$106,823;p<0.001) when compared to non-Black patients (NBP). Both groups were equally invited to an actual clinical trial (BPvs.NBP; 17.9%vs.21.7%;p=NS), however fewer BP reported that they would participate (17.1%vs.31.9%;p<.001). Patients with higher a Motivation Prediction Relevance Score (PRS) were 2.5 times more likely to join a trial (p=0.031), whereas those with a higher Religious PRS were 44% less likely to join (p=0.036). Compared to NBP, BP were more apt to agree that illness/death is determined by God's will, (48%vs.17.3%;p=0.024) and that God determines wellness, not research (55.1%vs.16.5%;p<0.001). Eighteen percent of BP agreed that research harms minorities vs.3.6% of NBP (p=.001). BP felt that there was nothing for them (11.8%vs.3.2%;p=0.01) or their community (25.1%vs.5.3%;p=0.006) to gain by participating in research when compared to NBPs. ≥90% of both groups trusted their cancer doctors.
Spiritual beliefs may play a key role in clinical trial decision-making among BP. Though most patients trust their cancer care team, there remains underlying distrust in clinical research among BP.

PMID:
42790602
Bibliographic data and abstract were imported from PubMed on 26 Sep 2026.

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