One million exomes identify FNIP1 as a metabolic brake.

Authors

Nobuyuki Enzan, Satoshi Koyama

Published in

Trends in genetics : TIG. Sep 25, 2026. Epub Sep 25, 2026.

Abstract

Exome sequencing of more than 1 million people uncovered dozens of genes linked to the biomarker of the body's energy state (Hindy et al.). Rare loss-of-function variants in FNIP1, a suppressor of mitochondrial energy expenditure, were associated with lower cardiometabolic disease risk, nominating selective FNIP1 inhibition as a therapeutic strategy.

PMID:
42791079
Bibliographic data and abstract were imported from PubMed on 26 Sep 2026.

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