Authors
Seyed Ahmad Raeissadat, Seyyede Elahe Mousavikhah, Ali Nazari Nodoushan, Amir Hossein Mahdi Kaghazi, Davood Khavari Ardestani, Fatemeh Rahmani, Hojjat Layegh
Published in
Future science OA. Volume 12. Issue 1. Pages 2722399. Epub Sep 25, 2026.
Abstract
Intra-articular therapies are widely used for knee osteoarthritis (KOA), but direct comparisons between emerging biomaterials such as hydrolyzed collagen (HC) and established options like platelet-rich plasma (PRP) and hyaluronic acid (HA) are limited.
To compare the efficacy of intra-articular PRP, HC, and HA on pain, stiffness, and functional outcomes in KOA.
In this randomized, assessor- and statistician-blinded trial, 135 patients with Kellgren-Lawrence grade 2-3 KOA were assigned (1:1:1) to receive three ultrasound-guided Intra-articular injections of PRP, HC, or HA at two-week intervals. The primary outcome was change in WOMAC total score at 6 months. Secondary outcomes included WOMAC subscales, VAS pain, and the Lequesne Index.
One hundred twenty-six patients completed follow-up. All groups showed significant improvements (p < 0.001). HA demonstrated greater improvements in some outcome measures at 1 month. PRP and HC demonstrated more sustained improvements than HA during 1 to 6 months follow-ups, although statistically significant between-group differences were limited to selected outcomes. No serious adverse events occurred.
Intra-articular PRP, HC, and HA improved outcomes in mild to moderate knee OA; PRP and HC showed a trend toward more sustained benefits during 1 to 6 months. Longer-term trials are necessary to confirm these findings.
PMID:
42791219
Bibliographic data and abstract were imported from PubMed on 26 Sep 2026.
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