Treadmill exercise improves motor deficits and partially normalizes electrophysiological properties of substantia nigra pars reticulata PV-lineage neurons in 6-OHDA-lesioned mice.

Authors

Wanchun Xue, Jianhua Zhang, Zhiyu Chen

Published in

Frontiers in physiology. Volume 17. Pages 1896949. Epub Sep 11, 2026.

Abstract

To examine whether treadmill exercise improves motor deficits and alters electrophysiological properties of substantia nigra pars reticulata (SNr) PV-lineage neurons in 6-OHDA-lesioned mice.
Male Pvalb-Cre;Ai14 mice were assigned to Sham, 6-OHDA-lesioned sedentary (PD), and 6-OHDA-lesioned treadmill-exercise (PD+EX) groups. A unilateral 6-OHDA lesion model was established by right striatal injection of 6-OHDA. PD+EX mice underwent treadmill training for 30 min/day, 5 days/week for 6 weeks. Motor function was assessed using a 10-min open-field test and three 300-s rotarod trials. Lesion verification, PV Western blotting, and whole-cell patch-clamp recordings of SNr PV-lineage neurons were performed.
Six weeks of treadmill exercise partially improved open-field and rotarod performance in 6-OHDA-lesioned mice. Exercise was also accompanied by partial normalization of several electrophysiological abnormalities in lesioned-side SNr PV-lineage neurons, including input resistance, action potential threshold, evoked firing capacity, F-I gain, and firing adaptation. No significant group differences in regional PV protein abundance were observed.
Treadmill exercise improved motor performance and was accompanied by partial normalization of the electrophysiological properties of SNr PV-lineage neurons in 6-OHDA-lesioned mice.

PMID:
42798371
Bibliographic data and abstract were imported from PubMed on 26 Sep 2026.

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