Authors
Nasrin Kakaei, Abbas Ahmadi, Veria Naseri, Arvin Shajeie, Bahram Nikkhoo, Maryamsadat Mirtalebiesfarjani, Sara Chavoshinezhad, Bijan Nori
Published in
Journal of biomedical materials research. Part B, Applied biomaterials. Volume 114. Issue 10. Pages e70157.
Abstract
Managing infected wounds requires a delicate balance between rapid antimicrobial activity and continued tissue repair. To meet this challenge, we developed a porous carboxymethyl cellulose (CMC)/alginate hydrogel loaded with Silver nanoparticles and a Pistacia atlantica essential oil rich in α-pinene. The hydrogel displayed remarkable swelling (up to 6362% over 72 h) and changed the essential oil release from a rapid, volatile burst to a sustained, controlled profile (73% steady release over 96 h). In vitro tests revealed potent antibacterial activity against Staphylococcus aureus (MIC = 650 μg/mL), significant antioxidant properties, and excellent cytocompatibility. Importantly, in vivo studies in mice demonstrated a stage-adaptive healing mechanism. Silver nanoparticles allowed rapid early infection control (47.4% wound closure by Day 4). Subsequently, the sustained release of the essential oil promoted robust tissue regeneration during the proliferative phase (82.6% closure by Day 7), driven by an enhanced TAC-mediated antioxidant defense, reduced MDA levels, and accelerated hydroxyproline-associated collagen synthesis. By Day 13, re-epithelialization was near-complete (93.6%), matching commercial controls. Ultimately, this synergistic integration of plant-derived bioactives and metal antimicrobials presents a highly effective, stage-specific platform for accelerated wound healing.
PMID:
42798198
Bibliographic data and abstract were imported from PubMed on 26 Sep 2026.
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