Association of the TyG-related indices with hypertension-diabetes comorbidity in middle-aged and older adults: a suburban community-based study.

Authors

Fanlian Kong, Yanting Ma, Junchang Zhao, Junying Tan, Shou Liu, Zhancui Dang

Published in

BMC cardiovascular disorders. Volume 26. Issue 1. Jul 25, 2026. Epub Jul 25, 2026.

Abstract

To investigate the associations between TyG-related indices and hypertension-diabetes comorbidity (HTN-DM) among middle-aged and older adults.
A total of 2854 participants (aged ≥ 45 years) living in a suburban community were included in this study. The collected information comprised three parts: baseline information, physical examination, and laboratory testing. Multivariable logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between TyG-related indices (TyG, TyG-BMI, and TyG-BRI) and HTN-DM. Restricted cubic splines (RCS) were used to model the dose-response relationships. Receiver operating characteristic (ROC) curves were applied to evaluate the discriminative performance of these indices.
Among 2,854 participants, each 1-SD increment in TyG, TyG-BMI, and TyG-BRI conferred multivariable-adjusted ORs (95% CIs) of 3.16(2.75-3.64), 1.39(1.15-1.66), and 1.37(1.22-1.54), respectively (all P < 0.001). Corresponding ORs (95% CIs) comparing the highest versus lowest quartile were 30.99(16.97-62.97), 6.42(4.20-10.14), and 6.43(4.21-10.17), with significant dose-response trends (all P for trend < 0.001). RCS analysis revealed a linear relationship for TyG and nonlinear associations for TyG-BMI and TyG-BRI with HTN-DM. TyG showed the highest observed AUC (0.786) among the evaluated indices, followed by TyG-BMI (0.679) and TyG-BRI (0.633).Across all subgroup analyses, TyG remained consistently and positively associated with HTN-DM prevalence, and the interaction with sex was significant (P = 0.045).
This study revealed that TyG-related indices were associated with HTN-DM. RCS analysis indicated a linear association for TyG but nonlinear associations for TyG-BMI and TyG-BRI. Among the three indices, TyG showed the highest observed AUC. This finding suggests that composite indices incorporating BMI or BRI may not necessarily improve discriminative ability beyond TyG alone.

PMID:
42800849
Bibliographic data and abstract were imported from PubMed on 27 Sep 2026.

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