Myocardial injury in oncology patients undergoing noncardiac surgery for MRONJ: risk factors and nutritional associations.

Authors

Yiwen Liu, Tao Zhu, Biao Zhou, Pei Wang, Ziran Yang, Mengyuan Yang, Ning An, Xueye Liu, Weiming Wang, Xue Chen, Yi Zhang, Yongping Ma, Yuxing Guo

Published in

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. Volume 34. Issue 10. Sep 26, 2026. Epub Sep 26, 2026.

Abstract

To investigate the incidence and risk factors of myocardial injury after noncardiac surgery (MINS) in oncology patients undergoing surgery for medication-related osteonecrosis of the Jaw (MRONJ).
This retrospective study analyzed 65 patients with oncology-related MRONJ who underwent surgical treatment between October 2024 and May 2025. High-sensitivity cardiac troponin I (hs-cTn I) levels were measured preoperatively and within 72 h postoperatively. MINS was diagnosed according to established criteria. Clinical characteristics were compared and analyzed between patients with and without MINS to evaluate associations among relevant variables.
Among the 65 patients, 7 (10.8%) developed MINS. Compared with patients without MINS, those with MINS had a significantly lower body mass index (BMI; P = 0.003), a higher prevalence of preoperative myocardial injury (P = 0.005), lower preoperative serum albumin levels (P = 0.039), and a significantly more severe anemia (P = 0.029). Spearman correlation analysis demonstrated a moderate positive correlation between MINS and preoperative myocardial injury (ρ = 0.435, P < 0.001) and a negative correlation between MINS and BMI (ρ = - 0.366, P = 0.003). Significant correlations were also observed among BMI, serum albumin levels, and anemia severity, suggesting an interaction between nutritional status and postoperative myocardial injury in MRONJ patients.
In this exploratory study, MINS in oncology-related MRONJ patients was observed to be associated with preoperative myocardial injury, low BMI, hypoalbuminemia, and anemia. These preliminary findings suggest that incorporating nutritional assessment and cardiac biomarker surveillance into perioperative evaluation may support risk stratification. However, these observed associations require confirmation in larger, prospective studies.

PMID:
42799895
Bibliographic data and abstract were imported from PubMed on 27 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.