Authors
Yerkyesh Khamit, Lei Huang, Yena Oh, Jinghan Su, Dilda Kaskadamova, Segon Jang, Weizhaole Wei, Sarah Lee, Eun Sil Kim, Youn Kyoung Son, Byong Chul Yoo, Jongsung Lee, Jae Youl Cho
Published in
Chemistry & biodiversity. Volume 23. Issue 9. Pages e71768.
Abstract
Duchesnea chrysantha (Zoll. & Moritzi) Miq. (Rosaceae) has traditionally been used in East Asian medicine for inflammatory and skin-related disorders. This study investigated the phytochemical composition and protective effects of D. chrysantha ethanol extract (Dc-EE) against ultraviolet B (UVB)-induced skin damage. Untargeted LC-MS/MS analysis tentatively annotated various phytochemical constituents, including flavonoids and phenolic acids. Dc-EE reduced UVB-induced oxidative stress, reactive oxygen species production, and apoptosis in human keratinocytes (HaCaT) and dermal fibroblasts (HDF). It also suppressed cyclooxygenase-2 and matrix metalloproteinases (MMP-1, MMP-2, and MMP-9) in HaCaT cells while restoring collagen type I alpha 1 expression in HDF cells. In addition, Dc-EE enhanced the expression of skin barrier- and hydration-related factors, including filaggrin, transglutaminase-1, and hyaluronan synthase-2. Dc-EE attenuated UVB-induced MAPK signaling by reducing JNK, ERK, and p38 phosphorylation, together with AP-1 and NF-κB transcriptional activities. Reduced activation of transforming growth factor-β-activated kinase 1, an upstream stress-responsive regulator, was also observed. These findings indicate that Dc-EE attenuates UVB-induced cellular damage through antioxidant, anti-inflammatory, and barrier-related effects, supporting its potential for skin protection.
PMID:
42801762
Bibliographic data and abstract were imported from PubMed on 28 Sep 2026.
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