Authors
Burak Bayrak, Ferhat Güneş, Beyzanur Akyüz, Elif Beyza Özer, Amenah Imad Abdulqader, Ayşe Çivaş, İsranur Küçüksu, Hatice Rümeysa Sönmez, Ömer Çeçen, Bilge Aydın, Furkan Çoban, Hafize Yuca, Songül Karakaya
Published in
Chemistry & biodiversity. Volume 23. Issue 9. Pages e71739.
Abstract
This study comparatively evaluated the phytochemical composition and bioactivities of methanolic extracts and aqueous decoctions obtained from seeds of two Fabaceae taxa (Gonocytisus angulatus, Podocytisus caramanicus). Aqueous decoction yielded higher extraction efficiencies (up to 39.20%), whereas methanolic extraction recovered a broader range of phenolic compounds. Phytochemical analysis revealed that flavonoids and phenolic acids were the dominant constituents, with chlorogenic acid, rutin, quercetin, kaempferol, and gallic acid as the major compounds, particularly enriched in methanolic extracts. In vitro assays demonstrated moderate enzyme inhibitory effects. The highest α-glucosidase inhibition was observed in the methanolic extract (20.22%), while α-amylase inhibition reached 30.11%. Anticholinesterase activity was also weak, with maximum acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition values of 15.27% and 19.93%, respectively. In contrast, antioxidant activity was more pronounced, with ABTS radical scavenging reaching 97.40%, comparable to the reference standard. Molecular docking supported these findings by indicating favorable binding interactions of major phenolic compounds with target enzymes.
PMID:
42801755
Bibliographic data and abstract were imported from PubMed on 28 Sep 2026.
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