[Clinical Characteristics Analysis of Primary Gastric Large B-Cell Lymphoma with IRF4 Rearrangement].

Authors

Chang-Ying Gu, He-Sheng He, Chen Huang, Jun-Ping Yao, Su-Fen Wang, Hua Jiang

Published in

Zhongguo shi yan xue ye xue za zhi. Volume 34. Issue 4. Pages 1006-1011.

Abstract

To investigate the clinical characteristics and diagnostic approaches for patients with primary gastric large B-cell lymphoma with IRF4 rearrangements (LBCL-IRF4), thereby enhancing understanding of this distinct subtype.
A retrospective analysis was conducted on the clinical presentation, diagnostic and therapeutic course, and prognosis of this single case of primary gastric LBCL-IRF4 treated in our hospital.
Based on pathological, imaging, and bone marrow examinations, the patient was diagnosed with LBCL-IRF4 (Stage ⅡA, IPI score: 1, low risk; NCCN-IPI score: 2, intermediate-low risk; CNS score: 1, low risk). The patient received four cycles of the R-CDOP regimen (rituximab + cyclophosphamide + vindersine + liposomal doxorubicin + prednisolone tablets) followed by two additional cycles of rituximab consolidation therapy. The patient achieved complete remission.
LBCL-IRF4 is clinically uncommon, and primary gastric LBCL-IRF4 is even rare. Such patients demonstrate favourable outcomes following standard treatment.

PMID:
42802436
Bibliographic data and abstract were imported from PubMed on 28 Sep 2026.

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