Serum NfL predicts visual recovery and neuronal loss after optic neuritis.

Authors

Gloria Dalla Costa, Marco Pisa, Roberto Furlan, Giancarlo Comi, Letizia Leocani

Published in

Multiple sclerosis (Houndmills, Basingstoke, England). Pages 13524585261489992. Sep 28, 2026. Epub Sep 28, 2026.

Abstract

Optic neuritis, a common manifestation of multiple sclerosis, involves acute axonal injury and variable visual recovery. We evaluated whether serum neurofilament light chain predicts visual and structural outcomes after first-episode optic neuritis. Fifty-one patients (mean age = 33 years, 71% women) were followed for 24 ± 6 months with low-contrast letter acuity testing and optical coherence tomography. Adjusting for age and sex, higher baseline serum neurofilament light chain predicted greater inter-eye differences in retinal nerve fibre layer (-4.65 µm per SD, p = 0.02), ganglion cell/inner plexiform layer (-1.39 µm, p = 0.02) and 2.5% low-contrast letter acuity (-0.73, p = 0.05), but not high-contrast acuity. Early serum neurofilament light chain may stratify optic neuritis severity and guide neuroprotective trial selection.

PMID:
42803270
Bibliographic data and abstract were imported from PubMed on 28 Sep 2026.

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