Discrepancies Between SNOT-22 Questionnaire, Objective Assessments, and Histopathologic Findings in Chronic Rhinosinusitis With Nasal Polyps.

Authors

Elchanan Zloczower, Eitan Shavit, Nir Tsur, Raviv Allon, Yuval Cohen, Naama Ronel, Yael Shapira-Galitz, Meir Warman

Published in

American journal of rhinology & allergy. Pages 19458924261492820. Sep 28, 2026. Epub Sep 28, 2026.

Abstract

BackgroundThe Sinonasal Outcome Test-22 (SNOT-22) is widely used to evaluate symptom burden in chronic rhinosinusitis with nasal polyps (CRSwNP), yet its relationship with objective disease measures, pathological features, and specific endotypes remains unclear.ObjectiveTo assess correlations between SNOT-22 scores, including subdomains, and clinical, radiologic, and histopathologic features in patients undergoing endoscopic sinus surgery (ESS) for CRSwNP.MethodsWe retrospectively reviewed records of 83 adult patients with CRSwNP treated with ESS at a single tertiary medical center between 2018 and 2024. All patients completed the SNOT-22 questionnaire and underwent preoperative computed tomography imaging. Nasal polyp scores (NPS), Lund-Mackay staging, and histopathologic characteristics were documented. Correlations between SNOT-22 domains and demographic, clinical, objective parameters, and histopathological findings were analyzed using appropriate statistical tests.ResultsThe mean preoperative SNOT-22 total score was 55.9 ± 23.5. No significant associations were observed between total SNOT-22 scores and Lund-Mackay staging, NPS, or clinical endotypes. Female sex correlated with higher rhinologic subdomain scores (P = .037). Higher NPS demonstrated an association with greater emotional burden (Pearson correlation coefficient = 0.249, P = .038). Among histopathologic features, tissue eosinophil count showed a nonsignificant trend toward higher emotional subdomain scores (P = .081). No other significant correlations were identified.ConclusionsIn this cohort, SNOT-22 scores and their subdomains showed limited correlation with objective measures of disease severity, radiologic burden, endotype classification, and histopathologic findings. These findings underscore the complex interplay between subjective symptom perception and objective disease markers in CRSwNP.

PMID:
42803799
Bibliographic data and abstract were imported from PubMed on 28 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.