Alzheimer's disease polygenic risk scores and postoperative delirium: A promising marker, but not yet a clinical tool.

Authors

Rômulo Rebouças Lôbo, Lucas Tadeu Rocha Santos, Arnaldo Aires Peixoto Junior, Danielle S Macedo

Published in

Journal of Alzheimer's disease : JAD. Pages 13872877261491985. Sep 28, 2026. Epub Sep 28, 2026.

Abstract

Recent advances in Alzheimer's disease (AD) biomarkers and genomics have raised interest in personalized approaches to related conditions such as postoperative delirium (POD). Chen et al. report a moderate association between AD polygenic risk scores (AD-PRS) and POD, suggesting genetic susceptibility as a marker of biological vulnerability. However, the clinical utility of AD-PRS remains uncertain, as the study does not demonstrate incremental predictive value over established clinical risk factors. At present, AD-PRS should be considered a research tool. Future studies should assess its predictive performance, cost-effectiveness, and ethical implementation in diverse populations.

PMID:
42803714
Bibliographic data and abstract were imported from PubMed on 28 Sep 2026.

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