The Role of STAG2, CDKN2A, and TP53 Genes in Ewing Sarcoma: A Report of a Rare Case of Primary Ewing Sarcoma of the Kidney With Favorable Outcome.

Authors

Alyssa M Greenwell, Avanti Gupte, Ali G Saad, Hamza S Gorsi

Published in

Journal of pediatric hematology/oncology. Volume 48. Issue 7. Pages e314-e317. Oct 01, 2026. Epub Jun 29, 2026.

Abstract

Primary renal Ewing sarcoma (EWS) is a rare but aggressive pediatric malignancy with poor outcomes and limited knowledge of its behavior and biology. The use of molecular markers as prognostic factors and local control strategies with surgical resection and radiation is not well-described for renal EWS.
We document a case of stage IV renal EWS with 4.5 years of durable remission.
We hypothesize the favorable outcome may be associated with the lack of specific genomic signatures (STAG2, CDKN2A, and TP53) and the use of upfront surgical resection followed by radiation for local control.

PMID:
42804587
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.

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