The Therapeutic Potential of Dihydroartemisinin in Cancer Treatment.

Authors

Zhaochuan Hu, Shuai Zhang, Yongqi Shi, Yunlei Song, Dan Miao, Wenhe Xiong, Jiaying Guo, Yumao Jiang

Published in

International journal of molecular sciences. Volume 27. Issue 8. Apr 10, 2026. Epub Apr 10, 2026.

Abstract

Dihydroartemisinin (DHA), the active metabolite of artemisinin derivatives, is a clinically established antimalarial agent that has recently gained significant attention for its anticancer properties. This review systematically examines the molecular mechanisms underlying DHA's antitumor effects and explores innovative strategies to enhance its bioavailability and therapeutic efficacy. DHA demonstrates substantial potential in combination therapies with conventional clinical agents, with its broad anticancer applications being strongly supported by both preclinical and clinical evidence. Furthermore, this article outlines future research directions, discusses challenges in clinical translation, and summarizes current scientific approaches addressing these limitations. Collectively, this review highlights DHA's promising role in cancer treatment and provides a foundation for developing improved therapeutic strategies.

PMID:
42074066
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.