Authors
Yingying Yao, Wangyan Zhong, Huiping Zhu, Xizhi Wu
Published in
Ear, nose, & throat journal. Pages 1455613261492902. Sep 28, 2026. Epub Sep 28, 2026.
Abstract
ObjectivesThis retrospective study aimed to investigate therapeutic patterns and survival outcomes among elderly patients with stage III-IVB clinically non-surgically managed locally advanced laryngeal cancer treated with radiotherapy (RT) alone or RT plus concurrent chemotherapy (CT).MethodsA retrospective analysis was conducted using data from the Surveillance, Epidemiology, and End Results (SEER) database. Atotal of 882 patients aged ≥65 years with stage III-IVB clinically non-surgically managed laryngeal squamous cell cancer (LSCC) diagnosed between 2010 and 2015 were identified. Kaplan-Meier survival analysis and log-rank tests were performed to compare outcomes between patients receiving RT alone (n=220) and those receiving RT plus CT (n=662).ResultsThe estimated 3-year overall survival (OS) and cancer-specific survival (CSS) rates were 50% and 58.7%, respectively. Univariate analyses identified age, clinical stage, N stage, and treatment modality as significant predictors of OS and CSS. Multivariate analyses demonstrated that treatment modality and age were independently associated with OS, whereas treatment modality, N stage, age, and T stage were independent predictors of CSS. Subgroup analyses revealed that patients with T3 or N2 disease achieved superior OS and CSS after treatment with RT plus CT.ConclusionRT plus CT was associated with improved survival outcomes in elderly LSCC patients with clinically non-surgically managed LSCC. Furthermore, this combination therapy provided significant survival benefits, particularly among patients with T3 or N2 disease.
PMID:
42805261
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.
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