Tau-PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head-to-head comparison of Flortaucipir and MK6240.

Authors

Isabella Bizzi, Arthur C Macedo, Lydia Trudel, Joseph Therriault, Nesrine Rahmouni, Firoza Z Lussier, Cécile Tissot, Gleb Bezgin, Étienne Aumont, Tevy Chan, Seyyed Ali Hosseini, Delphine Oliva-Lopez, Marina Pereira Gonçalves, Guilherme Povala, Pamela C L Ferreira, Bruna Bellaver, Livia Amaral, Emma Ruppert, Marina Scop Medeiros, Rayan Mroué, Andréia Rocha, Kok Pin Ng, Eduardo R Zimmer, Joseph Masdeu, Belen Pascual, Val J Lowe, Hwamee Oh, David N Soleimani-Meigooni, Juan Fortea, Zahinoor Ismail, Suzanne Baker, Tharick A Pascoal, Pedro Rosa-Neto, HEAD Study

Published in

Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 10. Pages e71861.

Abstract

We compared the association between mild behavioral impairment (MBI) and first- versus second-generation tau-positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD).
We assessed 110 individuals with head-to-head [¹⁸F]MK6240 and [¹⁸F]Flortaucipir tau-PET. Voxel-wise and region-of-interest analyses investigated relationships between tau-PET and MBI Checklist (MBI-C) scores, which were also compared across tau-PET positivity and PET-Braak stages.
For both tracers, MBI severity was associated with tau-PET signal in all Braak regions and increased across PET-Braak stages. [¹⁸F]MK6240 showed more extensive voxel-wise associations with MBI-C scores and additional correlations with affective symptoms in stratified analyses by diagnostic groups. Tau positivity was associated with a higher frequency of MBI. Individuals positive for [¹⁸F]MK6240 but negative for [¹⁸F]Flortaucipir exhibited greater MBI burden than individuals negative for both tracers.
MBI in early AD is associated with tau-PET, with [¹⁸F]MK6240 providing greater sensitivity to detect MBI-related symptoms.

PMID:
42805926
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.