Authors
Luca Vignatelli, Maurizio A Leone, Elisabetta Pupillo, Stefan Seidel, Ulf Kallweit, Natalia Colorado Prieto, Maria Lolich, Marina Tüzün, Claudio L A Bassetti
Published in
Sleep medicine reviews. Pages 102372. Sep 07, 2026. Epub Sep 07, 2026.
Abstract
Sleep quality is a determinant of health, and insomnia could be a risk factor for brain health. We searched MEDLINE and EMBASE (last search August 2025) to identify systematic reviews with meta-analysis (SMRAs) that evaluated insomnia as a predictive factor of dementia, stroke, depression, suicide, death, occupational injuries, and hospitalization. Sixteen SMRA were included, and three additional original systematic reviews were conducted for stroke, occupational injuries and hospitalization, as no published SMRAs were found on these topics. SRMAs consistently identified insomnia as a predictor of dementia, depression, suicide, while death was not associated with this disorder. Our two original SMRAs revealed that insomnia is a predictor of stroke (9 studies, 1,343,164 participants, HR = 1.26, 95%CI 1.05-1.53) and hospitalization for any reason (5 studies, 517,620 participants, OR = 1.28, 95%CI 1.14-1.43). With regard to occupational injuries, it was not possible to perform a meta-analysis of the results of the two studies retrieved (143,942 participants). Although an association was found with unintentional fatal injuries and with commuting injuries, data should be considered insufficient to draw a conclusion on this outcome. This work contributes to better defining the association between insomnia and the key descriptors of brain health and possible links to general health.
PMID:
42805805
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.
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