Cardiovascular risk factors and their evolution in a primary care psoriasis cohort: The REPICA study.

Authors

J A Heras-Hitos, A Segura-Fragoso, J Polo García, S Cinza-Sanjurjo, M E Montes-Belloso, S Velilla-Zancada, D Palacios-Martínez, A Pérez-Simón, C Vale-Varela, M R Martínez Guillamón, A I Rincón Ricote, V Pallarés-Carratalá

Published in

Semergen. Volume 52. Issue 8. Pages 102845. Sep 28, 2026. Epub Sep 28, 2026.

Abstract

To determine the incidence and evolution of cardiovascular risk factors in patients with psoriasis managed in a primary care setting in Spain, and to explore the occurrence of cardiovascular events and mortality during follow-up.
Observational, longitudinal, multicenter, prospective study including patients ≥45 years with psoriasis attended in primary care in Spain. Participants were enrolled between May 2019 and May 2021 and followed annually. Incidence rates (per 1000 patients/year) of cardiovascular risk factors were estimated. Cardiovascular events and mortality were analyzed as exploratory outcomes.
A total of 422 subjects were included (mean age 61.1 years; 51.4% male). At baseline, cardiovascular risk factors were highly prevalent (dyslipidemia 55%, hypertension 49%, diabetes 21%). Among patients with at least one follow-up visit (n=179; median follow-up 1.55 years), incidence rates per 1000 person-years were 49.05 for dyslipidemia, 30.48 for hypertension, 30.44 for obesity, and 14.90 for diabetes. Most patients showed stable psoriasis over time (∼80%). Exploratory analyses showed limited numbers of cardiovascular events and deaths, precluding robust inference.
Patients with psoriasis managed in primary care present a high burden and incidence of cardiovascular risk factors, which may develop over a relatively short follow-up period. These findings support the importance of early detection and adequate management of cardiovascular risk in this population.

PMID:
42804882
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.

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