Beyond risk scores: artificial intelligence representations of physiological resilience in surgical patients.

Authors

John Whittle, Evangelos Mazomenos

Published in

British journal of anaesthesia. Sep 28, 2026. Epub Sep 28, 2026.

Abstract

Current perioperative risk assessment relies largely on static models that estimate the probability of adverse outcomes using indirect, population-level proxies of physiological reserve. We argue that physiological resilience is better understood as an emergent, dynamic property of interacting biological systems, expressed within the broader context of surgical stress, anaesthetic care, and perioperative management. Modern artificial intelligence and machine learning architectures offer a paradigm shift, moving perioperative medicine beyond static risk calculators toward dynamic, multimodal representations of physiological state over time. Such representations provide the substrate for prescriptive analytics, actionable clinical decision support, and mechanism-informed perioperative care.

PMID:
42805891
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.

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