Cerebral Oxygenation is Associated with Neurodevelopmental Outcome in Infants Born Preterm with Intraventricular Hemorrhage.

Authors

Julia Elis, Renate Fuiko, Vito Giordano, Gregor Kasprian, Christa Nöhammer, Roxane Licandro, Klemens Vierlinger, Monika Olischar, Angelika Berger, Katharina Goeral

Published in

The Journal of pediatrics. Pages 115342. Sep 28, 2026. Epub Sep 28, 2026.

Abstract

To examine how cerebral oxygenation levels monitored by near-infrared spectroscopy (NIRS) are associated with neurodevelopmental trajectories in neonates with intraventricular hemorrhage (IVH).
In this prospective study, 95 neonates born at <34 weeks of gestation with IVH (63 males, median gestational age: 25⁺⁶ weeks) between 2013-2023 were included. Regional cerebral oxygen saturation (rScO₂) was monitored from IVH diagnosis until term-equivalent age. Analysis included rScO₂ levels, duration outside the normal range (<55%; >85%), fluctuations, and cerebral fractional tissue oxygen extraction (cFTOE). Neurodevelopment was assessed at 2-3 years.
Analysis of >20,500 hours of NIRS data revealed that impaired cerebral oxygenation was consistently associated with poorer outcome. Infants with severe cognitive, language, and motor impairment had significantly lower rScO₂ (p=0.001), spent more time with rScO₂ <55% (p=0.005), and exhibited higher cFTOE (p=0.001) than those with milder or no impairment. Exposure-based analysis demonstrated a clear dose-response relationship: infants in the lowest oxygenation quartiles had significantly worse outcome scores than those in the highest.
Impaired cerebral oxygenation in the early postnatal period is associated with poorer neurodevelopmental outcome in infants with IVH. Parameters such as rScO₂, time outside the normal range, and cFTOE were associated with long-term neurodevelopmental outcome. These findings support further investigations of cerebral oxygenation metrics in prospective studies of infants with IVH.

PMID:
42805550
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.

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