Authors
Binbin Nan, Jing Kang, Honghui Wei, Xiaojun Li, Qianming Chen, Zijian Cheng
Published in
Oral diseases. Sep 28, 2026. Epub Sep 28, 2026.
Abstract
Sleep regulates immune and inflammatory processes and may influence periodontal health, though evidence remains inconsistent. This meta-analysis evaluated the association between sleep characteristics, including sleep quality and sleep duration, and periodontal disease (PD).
Systematic searches up tos May 2025 identified eligible studies. Sleep-related exposures were assessed using validated questionnaires or sleep duration (< 7 h); periodontal outcomes were defined by clinical examination or self-report. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model, depending on heterogeneity.
Fourteen studies (n = 126,425) met inclusion criteria, of which nine (n = 55,524) provided adjusted odds ratios for meta-analysis. Six assessed questionnaire-based sleep quality and three assessed sleep duration alone. Across these heterogeneous exposure definitions, adverse sleep characteristics were associated with greater odds of PD (OR = 1.25; 95% CI: 1.11-1.41; p < 0.001, I2 = 53.8%). Sensitivity analyses showed no substantial change in the pooled estimate, and no statistically significant evidence of publication bias was detected.
Adverse sleep characteristics were associated with greater odds of PD, with a stronger association observed for severe periodontitis in subgroup analysis. However, the certainty of evidence was very low, and prospective studies are warranted to clarify causality.
PMID:
42806420
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.
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