A retrospective multicenter study: postoperative prognostic value of the lymphocyte-C-reactive protein ratio combined with the Ki-67 index in gallbladder cancer.

Authors

Haijian Wang, Shuqing Xu, Jianwu Liu

Published in

Updates in surgery. Sep 28, 2026. Epub Sep 28, 2026.

Abstract

We investigated the predictive value of the lymphocyte-to-C-reactive protein ratio (LCR) and Ki-67 index for postoperative prognosis in gallbladder cancer (GBC). This study included 180 patients with GBC who underwent radical resection, with 2-year postoperative recurrence-free survival (RFS) as the primary endpoint. Patients were divided into event (70 cases) and event-free (110 cases) groups depending on the occurrence of RFS. Ki-67 expression in tumor tissues was detected by immunohistochemistry. Univariate Cox regression and least absolute shrinkage and selection operator-Cox regression were adopted to explore the correlations of LCR and Ki-67 index with postoperative RFS, with Kaplan-Meier survival analysis and receiver operating characteristic curve analysis to evaluate their impacts on postoperative RFS and assess their predictive efficacy. The event group had lower LCR and higher Ki-67 index versus the event-free group. During follow-up, 70 RFS events (38.89%) and 30 OS events (16.67%) were observed. Low LCR and high Ki-67 index were linked to shorter RFS. Multivariate Cox analysis confirmed LCR (HR = 0.144, 95%CI: 0.064-0.325, P < 0.001) and Ki-67 index (HR = 1.058, 95%CI: 1.025-1.091, P < 0.001) to be independently correlated with RFS. Their combination showed moderate predictive performance for 2-year postoperative RFS events. GBC patients with postoperative RFS events present lower preoperative LCR and higher tumoral Ki-67 index. The two biomarkers are independently related to postoperative RFS, showing certain predictive value for 2-year postoperative RFS events. They are promising tools for postoperative risk stratification and adjuvant treatment decision-making in patients with GBC.

PMID:
42806233
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.

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