Authors
Zachary Popp, Allison James, Marco Chivardi, Cameron J Reimer, Charlotte Robbins, Tara Jenson, Jeroen M van Baar, Peter James, Kevin J Lane, Marcia Pescador Jiménez
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 10. Pages e71841.
Abstract
External exposome research offers opportunities to evaluate complex relationships between multiple environmental determinants of Alzheimer's disease and related dementias (ADRD). However, selecting specific exposure domains, identifying metrics, and downloading, processing, and managing big data are key challenges in translating the potential of exposome research into empirical data analyses. To overcome these issues, we have established a reproducible system that protects data privacy, setting the stage for an unparalleled examination of associations between environmental exposures and ADRD risk within an exposome framework. In this perspective, we provide a comprehensive guide, including examples, to linking natural, built, and social environment metrics to nationwide time-varying participants' residential address data. Further, as a proof of concept, we report descriptive statistics and spatial distribution of external exposome metrics across the contiguous United States in 2015. The external exposome can be securely and comprehensively characterized across multiple cohorts using this highly scalable approach.
PMID:
42805944
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.
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