A Well-Defined, Air-Stable NHC-Ni Precatalyst for C-N Bond Formation.

Authors

Kianoosh Masoomi, Jürgen Schulmeister, Michael G Organ

Published in

Chemistry (Weinheim an der Bergstrasse, Germany). Pages e71749. Sep 29, 2026. Epub Sep 29, 2026.

Abstract

A new, well-defined, air-stable N-heterocyclic carbene nickel(II) precatalyst [(IPr)Ni(N-methylphenethylamine)Cl] (IPr = N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) was designed, synthesized, and evaluated for C-N cross-coupling reactions. This precatalyst is readily activated in the presence of base and efficiently promotes the amination of a variety of aryl chlorides with amines. Optimization studies established robust reaction conditions and revealed the influence of electronic and steric properties of the coupling partners on catalytic performance. The combination of operational simplicity, long-term bench stability, and facile activation makes this NHC-Ni precatalyst a good choice for nickel-catalyzed C-N bond formation.

PMID:
42806766
Bibliographic data and abstract were imported from PubMed on 29 Sep 2026.

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