Osseous metaplasia in neoplastic and non-neoplastic lesions: A comprehensive case series of 30 patients from a tertiary care center.

Authors

Neeti Goyal, Kritika Dewan, Navdeep Singh, Umesh Kapoor, Vandana Rana, Pragya Sharma, Prabha S Mishra, Shamresh Singh, Paresh Singhal, Arun Gupta

Published in

Indian journal of pathology & microbiology. Sep 28, 2026. Epub Sep 28, 2026.

Abstract

Osseous metaplasia (OM), distinct from calcification, is a rare histological event reported across various organs in both neoplastic and non-neoplastic contexts, typically as isolated case reports.
This study presents a series of 30 cases of OM from diverse anatomical sites, aiming to broaden the understanding of its pathogenesis and clinical significance.
A retrospective and prospective histopathological study was conducted over 12 months (August 24 to August 25) in a tertiary care center. Inclusion criteria encompassed all cases of OM confirmed on histology; cases lacking sufficient clinical or tissue data were excluded.
Eighteen cases (19 males, 11 females; age range: 31-74 years) were included. The most frequent sites were the thyroid, kidney, followed by lung, bladder, endometrium, and breast.
This is one of the largest single-center series documenting OM across a spectrum of lesions. Recognizing OM can aid in accurate histological interpretation and may have prognostic value in certain tumors.

PMID:
42809728
Bibliographic data and abstract were imported from PubMed on 30 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.