Authors
L H Lyu, X W Ye, F Zhang, C Ji, J M Su
Published in
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. Volume 61. Issue 10. Pages 1456-1465. Sep 30, 2026. Epub Sep 30, 2026.
Abstract
Objective: To investigate the oral health status of Chinese children with Williams syndrome (WS), providing a basis for the comprehensive prevention, treatment, and early intervention of oral diseases associated with this syndrome. Methods: This was a cross-sectional descriptive study. A total of 137 children with WS aged 3 to 12 years who visited the Department of Stomatology at the Children's Hospital, Zhejiang University School of Medicine from January 2023 to May 2025 were enrolled and divided into two groups: 81 children aged 3 to 5 years and 56 children aged 6 to 12 years. All participants underwent routine oral examinations. Oral health status was assessed from three aspects: dental caries indicators, dental developmental anomalies, and malocclusion. The distribution of oral phenotypes was compared across age groups and between the sexes. Caries indicators were also compared with those of same-aged children from the Fourth National Oral Health Epidemiological Survey of China (2018). Univariate and multivariate logistic regression analyses were used to explore factors independently associated with malocclusion. Results: Children with WS exhibited prominent oral health problems. Regarding dental caries, in the 3 to 5 years group, the prevalence of caries in primary teeth was 64.2% (52/81), with dmft (decayed, missing, and filled teeth) of 4.48±2.39 and a caries filling ratio of 6.8%(17/249). In the 6 to 12 years group, the prevalence of caries in primary teeth was 76.8% (43/56), with dmft of 4.89±3.12 and a caries filling ratio of 23.7% (65/274); the prevalence of caries in permanent teeth in the same group was 23.2% (13/56), with a mean DMFT (Decayed, Missing, and Filled Teeth) of 0.46±1.05 and a caries filling ratio of 19.2% (5/26). Regarding dental developmental anomalies, congenital tooth agenesis and incisor morphological anomalies were the most common findings. The prevalence of congenital tooth agenesis was 35.8% (29/81) in the 3 to 5 years group and 66.1% (37/56) in the 6 to 12 years group. The prevalence of incisor morphological anomalies was 64.2% (52/81) and 60.7% (34/56) in two groups, respectively. The overall prevalence of malocclusion was 66.7% (54/81) in the 3 to 5 years group, with the top three types being diastema [43.2% (35/81)], crossbite [23.5% (19/81)], and deep overbite [19.8% (16/81)]. In the 6 to 12 years group, the prevalence was 32.1% (18/56), with the top three being increased overjet [35.7% (20/56)], deep overbite [33.9% (19/56)], and diastema [33.9% (19/56)]. Multivariate Logistic regression analysis showed that high caries status [adjusted odds ratio (aOR)=2.26, 95% confidence interval (CI): 1.01-5.05, P=0.046] and congenital tooth agenesis (aOR=2.86, 95%CI: 1.26-6.52, P=0.012) were independently associated with malocclusion. Conclusions: Children with WS exhibit high prevalences of dental caries, developmental anomalies, and malocclusion, along with poorer oral health than typically developing children. A comprehensive management plan should include regular oral check-ups, active caries prevention, monitoring of developmental anomalies, and early orthodontic intervention. In addition, a multidisciplinary team approach is recommended.
PMID:
42811704
Bibliographic data and abstract were imported from PubMed on 30 Sep 2026.
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