Authors
Jun Ma, Ruochen Liu, Ibrahim Chamseddine, Jingjing Qiu, Shiren Wang
Published in
Macromolecular bioscience. Volume 26. Issue 10. Pages e70267.
Abstract
Poor penetration into tumor tissue remains a major barrier to effective nanomedicine delivery, particularly in glioblastoma multiforme (GBM). Here, nanoparticle transport was computationally studied to rationally design an ultrasmall chemotactic nanomotor that improves penetration into dense tumor tissue. The nanomotor comprises a targeting human heavy-chain ferritin (HFn) nanocage and a catalytic cerium oxide (CeO2) component. Leveraging transferrin receptor‑1 overexpression on brain microvascular endothelial cells and GBM cells, HFn enables transport across an in vitro blood-brain barrier (BBB) model and accumulation in GBM spheroids. The CeO2 domain catalyzes hydrogen peroxide decomposition in the tumor‑mimicking microenvironment, generating oxygen and imparting directional propulsion along H2O2 gradients. In chemotaxis assays, the nanomotors actively migrated toward localized H2O2 sources and GBM cells embedded in Matrigel. In large U87 spheroids (>400 µm), HFn@CeO2 nanomotors penetrated deeply and distributed throughout the spheroid core, whereas non‑propelled HFn nanocarriers remained confined mainly to the periphery. Doxorubicin‑loaded nanomotors (HFn@CeO2-DOX) achieved substantially enhanced intratumoral DOX distribution and reduced IC50 (0.33 µM) compared with HFn-DOX (1.13 µM) and free DOX (1.75 µM) in GBM spheroids. These results provide a promising basis for future in vivo evaluation in brain tumor therapy.
PMID:
42814085
Bibliographic data and abstract were imported from PubMed on 30 Sep 2026.
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