Authors
Jin Wang, Junfeng Wu, Ziqi Yang, Yihao Pei, Fance Meng, Jianmei Han
Published in
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery. Sep 30, 2026. Epub Sep 30, 2026.
Abstract
To characterize trial design, endpoint emphasis and public results reporting in interventional laryngeal cancer studies.
Registry-based descriptive study of trial records.
ClinicalTrials.gov; records were retrieved on 28 July 2025.
Interventional trials retrieved using the term 'laryngeal cancer' and with a documented start date between 1988 and 2025.
Trial phase, planned enrolment, design features, intervention strategies, registered endpoint domains, results posting and discontinuation.
We identified 404 trials. Most were early-to mid-phase with modest enrolment, and masking was recorded in 10.6%. Randomization was documented in 34.7% overall and was more frequent in 2009-2025 than in 1988-2008. Across three study eras, the proportion of trials specifying survival endpoints increased from 34.2% to 68.4%. Quality-of-life or patient-reported endpoints increased from 11.0% to 36.8%, and swallowing endpoints increased from 6.3% to 17.1%. Voice endpoints remained uncommon (3.8%-6.6%), and 21 trials (5.2%) specified an explicit larynx-preservation endpoint. Results were posted for 23.5% of trials, and 16.1% were discontinued.
Registrations increasingly reflect survival and patient-centred priorities, although explicit larynx-preservation endpoints and publicly posted results remain uncommon. Future trials may benefit from larynx-specific designs, consistent assessment of larynx preservation and function with adequate follow-up, and timely dissemination of results.
PMID:
42813420
Bibliographic data and abstract were imported from PubMed on 30 Sep 2026.
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