Occupational chronic myeloid leukaemia in a radiology technician: a quantitative Probability of Causation assessment.

Authors

Elif Reyhan Sahin, Aysu Timuroglu, Elif Sedanur Utlu

Published in

Radiation protection dosimetry. Sep 30, 2026. Epub Sep 30, 2026.

Abstract

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative neoplasm associated with the Philadelphia chromosome, and ionizing radiation is a well-established leukemogenic factor. Despite regulated dose limits, occupationally related CML remains rare and under-recognized. We present the case of a 53-year-old male radiology technician diagnosed with CML following the detection of leukocytosis during routine periodic fitness-for-work surveillance. The patient had 29 years of documented occupational exposure with a cumulative effective dose of 150 mSv, without acute incidents. While International Commission on Radiological Protection recommendations primarily focus on fitness-for-work rather than malignancy screening, this case-the first officially recognized and institutionally attributed occupational CML in our country-demonstrates how systematic surveillance can facilitate the identification of serious haematological conditions in high-exposure (Class A) workers. It provides a structured Probability of Causation assessment to support occupational attribution and statutory recognition within a regulated low-dose environment on a probabilistic basis.

PMID:
42814020
Bibliographic data and abstract were imported from PubMed on 30 Sep 2026.

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